Methylation detection and analysis technology focused on human host gene EPB41L3 and hrHPV genes can accurately detect prevalent cervical cancer and high-grade precancerous lesions (CIN3)1.
Methylation test can predict cervical cancer many years before current methods of diagnosis2.
Methylation test as triage can reduce unnecessary colposcopy referrals3.
Methylation test can predict the progression of CIN24.
careREVEAL® Advantages:
1、High clinical sensitivity and specificity
2、Accurate, robust, and accessible
3、Non-invasive
4、Easy-to-use
careREVEAL® Applications:
1、Improved replacement for repeat cytology and HPV16/18 genotyping
2、Triage for hrHPV positive women or women with cytology ASCUS/LSIL
3、Active management of CIN lesions
1. Lorincz AT., Acta Cytologica (2016) 60 (6): 501–512
2. Cook DA., Int. J. Cancer: 144, 2587–2595 (2019)
3. Gu et al., Clinical Epigenetics (2020) 12:57
4. Louvanto & Lorincz, et al. Clin Infect Dis. 2020 Jun 10;70(12):2582-2590
2. Cook DA., Int. J. Cancer: 144, 2587–2595 (2019)
3. Gu et al., Clinical Epigenetics (2020) 12:57
4. Louvanto & Lorincz, et al. Clin Infect Dis. 2020 Jun 10;70(12):2582-2590
